Reaction Development, Natural Product Synthesis, Molecular Pharmacology

Publications

1. C. Tsukano, D. R. Siegel, S. J. Danishefsky "Differentiation of Nonconventional "Carbanions" The Total Synthesis of Nemorosone and Clusianone." Angew. Chem. Int. Ed. 2007, 46, 8840-8844.

2. D. R. Siegel, S. J. Danishefsky "Total Synthesis of Garsubellin A." J. Am. Chem. Soc. 2006, 128, 1048-1049.

3. H. Liu, D. R. Siegel, S. J. Danishefsky "Studies Directed Toward the Synthesis of Terreulactone A: Rapid Synthesis of the A, B, C Rings." Org. Lett. 2006, 8, 423-425.

4. M. G. Charest, D. R. Siegel, A. G. Myers. "Synthesis of (-)-Tetracycline." J. Am. Chem. Soc. 2005, 127, 8292-8293.

5. M. G. Charest, C. D. Lerner, J. D. Brubaker, D. R. Siegel, A. G. Myers. "A Convergent, Enantioselective Synthetic Route to Structurally Diverse 6-Deoxytetracycline Antibiotics." Science 2005, 308, 395-398.

6. D. R. Siegel, "Towards the Synthesis of (-)-Tetracycline: Developments of an Approach Initiated by the Microbial Dihydroxylation of Benzoic Acid." Harvard University Ph.D. Thesis, 2003.

7. A. G. Myers, D. R. Siegel, D. J. Buzard, M. G. Charest. "Synthesis of a Broad Array of Highly Functionalized, Enantiomerically Pure Cyclohexanecarboxylic Acid Derivatives by Microbial Dihydroxylation of Benzoic Acid and Subsequent Oxidative and Rearrangement Reactions." Org. Lett. 2001, 3, 2923-2926.

8. P. B. Alper, C. Meyers, A. Lerchner, D. R. Siegel, E. M. Carreira. "Facile, Novel Methodology for the Synthesis of Spiro[pyrrolidin-3,3'-oxindoles]: Catalyzed Ring Expansion Reactions of Cyclopropanes by Aldimines." Angew. Chem. Int. Ed. 1999, 38, 3186-3189.